Fine Lines + Wrinkles

Skin with fine lines, wrinkles, dark spots, and acne will benefit from VX.2. For skin types that can tolerate it, this formula can be customized with our highest levels of tretinoin, a prescription retinoid that sparks cellular turnover and repair. Our dermatologists can also personalize formulas with a lower concentration for sensitive skin. And if you tell us in the skin quiz that you have hyperpigmentation and/or acne, we'll add in ingredients to treat those too.

Because Cottonball blends the best of Rx with the best of cosmetic ingredients, our formulas are built to have immediate and long-term results. Our blend of hyaluronic acid creates an immediate plumping effect. In a few weeks, other actives will start to kick in with subtle but meaningful anti-aging changes. Your skin may feel smoother and softer. Around three months, you should see noticeable improvement in line-reduction, which will continue to transform the longer you use the product.

There's no time limit. To continue achieving benefits and maintain results, it's best to keep using this product.

If you are pregnant or nursing, you should not use products that contain tretinoin, found in VX.1. Anyone with a known allergy or irritation to any of the ingredients should also avoid VX.1. See more in our safety information.

While Cottonball formulas are meant to work with your existing favorite skincare products, you won't need to use a retinol at the same time as VX.2. Retinol is a less-potent, over-the-counter form of a retinoid. VX.2 contains the prescription retinoid tretinoid. Doubling up could be too irritating for skin. When you order any Cottonball treatment, we'll provide clear instructions on how to work in your new and existing products, and our dermatologists are available any time to answer any specific questions about your regimen.

Cottonball treatments are 100% personalized for your skin. So if you tell us in the skin quiz that your skin is sensitive or that you've had negative issues with retinoids before, your product will be formulated with a lower level of our prescription retinoid, tretinoin; it will also be infused with dexpanthenol, an irritation-reducing vitamin B5 derivative that is often used in wound healing. Our dermatologists will likely also recommend increasing use of VX.2 very slowly. For example, once weekly for weeks 1-4; twice weekly for weeks 5-8; and potentially three times weekly in weeks 9+.

Thanks to our 100% personalized formulas, we aim to prevent irritation from the start. But if you're not happy with your product, we offer free reformulations. Simply log in to your member account and let us know what's going on with your skin. One of our dermatologists will help refine the blend until it works for you.

When you take our skin quiz, you'll be able to tell us whether acne is a concern or not. Those who do not have acne-prone skin or a history of acne will not get azelaic acid in their personalized formula.

If you're using red light therapy, treat with the red light first, and then apply VX.2 afterwards. Going in the opposite order can make tretinoin, a key ingredient in VX.2, break down and become less effective.

Tretinoin, the prescription retinoid found in VX.2, has been shown to reduce fine lines and wrinkles. VX.2 also contains matrixyl 3000, a blend of peptides shown to also stimulate collagen production; by doing this, tretinoin plus matrixyl can help tighten skin. However, VX.2 is not meant to reverse the significant sagging skin that occurs with GLP-1-induced weight loss.